C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/095 (2006.01) C07K 14/22 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2260079
The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis, but not in Neisseria gonorrhoeae, or in Neisseria lactamica except the genes involved in the biosynthesis of the polysaccharide capsule, frpA, frpC, opc, porA, rotamase the sequence IC1106, IgA protease, pilline, pilC, transferrin binding proteins and opacity proteins. The invention also concerns the polypeptides corresponding to these DNA and the antibodies directed against these polypeptides. It is applicable in the prevention and the detection of meningococcus induced infections and meningitis.
Les ADN de l'invention sont caractérisés en ce qu'il s'agit de tout ou partie de gènes, avec leur phase de lecture, présents chez Neisseria meningitidis, mais absents soit chez Neisseria gonorrhoeae, soit chez Neisseria lactamica à l'exception des gènes impliqués dans la biosynthèse de la capsule polysaccharidique, frpA, frpC, opc, porA, rotamase, de la séquence IC1106, des IgA protéases, de la pilline, de pilC, des protéines qui lient la transferrine et des protéines d'opacité. L'invention vise également les polypeptides correspondant à ces ADN et les anticorps dirigés contre ces polypeptides. Applications à la prévention et à la détection d'infections à méningocoques et de méningites.
Achtman Mark
Merker Petra
Nassif Xavier
Ruelle Jean-Louis
Tinsley Colin
Institut National de La Sante Et de La Recherche Medicale (inser
Max Planck Gesellschaft Zur Forderung Der Wissenschaften E.v.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
Smithkline Beecham Biologicals S.a.
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