C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/711 (2006.01) A61P 7/02 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2528686
The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions. The cathepsin G- inhibiting aptamers according to the invention consist of linear DNA or polynucleotide sequences having a chaing length of at least 60 nucleotides and being substantially not subjected to undergo efficient base pairing.
La présente invention a trait à l'identification d'inhibiteurs non peptidiques de la cathepsine G caractérisés par des niveaux élevés de sélectivité et qui peuvent être utilisés de manière efficace dans le traitement et la prophylaxie d'apparitions de symptômes inflammatoires et de conditions de procoagulation. Les aptamères inhibiteurs de la cathepsine G selon l'invention sont constitués de séquences linéaires d'ADN ou de polynucléotides présentant une longueur de chaîne d'au moins 60 nucléotides et sont sensiblement non aptes à être soumis à un appariement des bases.
Ferro Laura Iris
Gatto Barbara
Palumbo Manlio
Pescador Rodolfo
Porta Roberto
Gentium Spa
Riches Mckenzie & Herbert Llp
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