Dna binding proteins including androgen receptor

C - Chemistry – Metallurgy – 12 – N

Patent

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530/13, 167/139,

C12N 15/10 (2006.01) C07K 14/47 (2006.01) C07K 14/72 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 5/12 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01)

Patent

CA 1341305

Disclosed are DNA sequences encoding DNA bind- ing polypeptides including androgen receptor (AR) and TR2 polypeptides. Illustratively, human and rat AR-cDNA have 79 kD and 98 kD polypeptide expression products which are immunoprecipitable by human auto-immune anti- androgen receptor antibodies and are capable of binding androgens specifically and with high affinity. Also disclosed are antibodies and immunological methods and materials for detection of androgen receptor and TR2 polypeptides and hybridization methods and materials for detection of AR and TR2-related nucleic acids.

595031

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