Dna capable of site-specific integration into mycobacteria

Details Dna capable of site-specific integration into mycobacteria Dna capable of site-specific integration into mycobacteria

C - Chemistry, Metallurgy

12

N

C12N 15/74 (2006.01) A61K 39/04 (2006.01) C07K 14/16 (2006.01) C12N 1/21 (2006.01) C12N 15/90 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2045842

ABSTRACT OF THE DISCLOSURE A DNA for integrating DNA into a mycobacterium chromosome which includes a first DNA sequence which is a phage DNA portion encoding bacteriophage integration into a mycobacterium chromosome, and a second DNA sequence encoding a protein or polypeptide heterologous to the mycobacterium in which the DNA is to be integrated. Such DNA may be integrated into mycobacteria, which may then be administered as a vaccine and/or therapeutic agent.

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