Dna coding for a signal amino acid sequence and dna...

C - Chemistry – Metallurgy – 12 – N

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195/1.22, 195/1.

C12N 15/00 (2006.01) C07H 21/04 (2006.01) C12N 9/28 (2006.01) C12N 15/75 (2006.01)

Patent

CA 1219826

Abstract of the Disclosure This invention relates to DNA consisting of a DNA base sequence coding for the signal amino acid sequence: Met Phe Ala Lys Arg Phe Lys Thr Ser Leu Leu Pro Leu Phe Ala Gly Phe Leu Leu Leu Phe Tyr Leu Val Leu Ala Gly Pro Ala Ala Ala Ser Ala Glu Thr Ala Asn Lys Ser Asn Glu, and to DNA containing such a DNA base sequence. The DNA base sequence coding for said amino acid sequence includes, for example, ATG TTT GCA AAA CGA TTC AAA ACC TCT TTA CTG CCG TTA TTC GCT GGA TTT TTA TTG CTG TTT TAT TTG GTT CTG GCA GGA CCG GCG GCT GCG AGT GCT GAA ACG GCG AAC AAA TCG AAT GAG. The desired products in cells can be secreted out of cells by the use of a vector containing DNA consisting of the DNA base sequence coding for said signal amino acid sequence.

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