Dna coding for growth-inhibitory factor and use thereof

Details Dna coding for growth-inhibitory factor and use thereof Dna coding for growth-inhibitory factor and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 1/21 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2077350

2077350 9210568 PCTABS00013 A DNA which codes for a novel protein GIF which inhibits neurotrophic activity and which is present in the brain of a healthy man but is not in the brain of a patient with Alzheimer's disease has been cloned from a human cerebral cDNA library and a human genome DNA library. Escherichia coli has been transformed by a vector containing the cDNA integrated thereinto to express the GIF. The DNA which codes for a cloned GIF can be used in the genetic diagnosis and treatment of Alzheimer's disease and a large amount of the GIF can be produced by expressing said DNA in a transformant.

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