A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/502 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2547077
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
L'invention concerne la reconnaissance du fait que l'inhibition de la voie de réparation d'excision de base est sélectivement létale dans des cellules qui sont déficientes en réparation d'ADN DSB dépendant de la HR. L'invention concerne des procédés et des moyens se rapportant au traitement de cancers qui sont déficients en réparation d'ADN DSB dépendant de la HR à l'aide d'inhibiteurs qui ciblent des composants de réparation d'excision de base, par exemple PARP.
Ashworth Alan
Jackson Stephen
Martin Niall
Smith Graeme
Kirby Eades Gale Baker
Kudos Pharmaceuticals Limited
The Institute Of Cancer Research
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