Dna diagnostics based on mass spectrometry

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) B01J 19/00 (2006.01) B01L 3/02 (2006.01) C07B 61/00 (2006.01) C07F 9/24 (2006.01) C07H 21/00 (2006.01) G01N 35/10 (2006.01) G01N 35/00 (2006.01)

Patent

CA 2270132

Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

L'invention concerne des procédés rapides et extrêmement précis fondés sur la spectrométrie de masse pour détecter une séquence d'acide nucléique particulière dans un échantillon biologique. En fonction de la séquence à détecter, ces procédés peuvent s'utiliser, par exemple, pour diagnostiquer une maladie génétique ou une anomalie chromosomique, une prédisposition à une maladie ou à un état pathologique, une infection par un organisme pathogène, ou bien pour déterminer l'identité ou l'hérédité.

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