Dna dosage forms

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/70 (2006.01) A61B 17/20 (2006.01) A61K 9/16 (2006.01) A61M 37/00 (2006.01) C12N 15/89 (2006.01) A61K 9/14 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2473679

The present invention relates to efficient devices for administration of DNA based pharmaceutical agents into mammalian skin. In a particularly preferred aspect of the present invention there is provided devices for administration of DNA vaccines into the skin of the mammal, and preferably into human skin. The present invention provides a microneedle DNA pharmaceutical agent delivery device having at least one skin-piercing element which comprises a support member coated with a solid reservoir medium containing, in solid solution or suspension within it, the DNA pharmaceutical agent, and a stabilising agent that inhibits the degradative effects of free radicals. Preferably the solid pharmaceutical reservoir medium coated onto such devices is a polyol, preferably being a polyol in an amorphous state (such as a glass).

La présente invention concerne des dispositifs efficients d'administration d'agents pharmaceutiques à base d'ADN dans la peau d'un mammifère. Dans un aspect particulièrement préféré de l'invention, on décrit des dispositifs destinés à l'administration de vaccins à base d'ADN dans la peau d'un mammifère et, de préférence, dans la peau d'un humain. L'invention concerne également un dispositif à micro-aiguille, servant à administrer un agent pharmaceutique à base d'ADN. Le dispositif à micro-aiguille comporte au moins un élément de percement de la peau, qui comprend un excipient enrobé d'un milieu réservoir solide contenant, dans une solution ou une suspension solide, l'agent pharmaceutique à base d'ADN, et un stabilisant qui inhibe les effets de dégradation de radicaux libres. De préférence, le milieu réservoir pharmaceutique solide enrobant lesdits dispositifs est un polyol, de préférence un polyol à l'état amorphe (tel que du verre).

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