Dna encoding a grf precursor

Details Dna encoding a grf precursor Dna encoding a grf precursor

C - Chemistry, Metallurgy

12

N

530/13, 195/1.22

C12N 15/18 (2006.01) C07K 14/60 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1299119

DNA ENCODING A GRF PRECURSOR ABSTRACT OF THE DISCLOSURE mRNAs encoding for GRF sequences are identified in a pancreas tumor and sequenced. From the sequence, it is learned that hpGRF is initially a portion of a longer precursor peptide that is subsequently processed into hpGRF. cDNA made from such mRNA is transformed into a host cell which produces a GRF precursor. In vitro or in vivo processing can be used to obtain GRF from the precursor.

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