Dna encoding a human melanin concentrating hormone receptor...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/16 (2006.01) A01K 67/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) A61M 1/36 (2006.01) C07H 21/04 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/00 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2358687

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense aligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

La présente invention concerne un acide nucléique isolé codant un récepteur humain MCH1, un récepteur humain MCH1 purifié, des vecteurs contenant un acide nucléique isolé codant ce récepteur, des cellules contenant de tels vecteurs, des anticorps dirigés contre un récepteur humain MCH1, des sondes nucléiques utiles dans la détection d'acide nucléique codant des récepteurs humains MCH1, des nucléotides antisens complémentaires à des séquences uniques d'acide nucléique codant des récepteurs humains, des animaux non humains, transgéniques, qui expriment un ADN codant un récepteur humain MCH1 normal ou mutant, des procédés destinés à isoler un récepteur humain MCH1, des méthodes de traitement de trouble dû à l'activité d'un récepteur humain MCH1, aussi bien que des méthodes permettant de déterminer des liaisons de composés aux récepteurs mammaliens MCH1.

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