C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/16 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/715 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2384026
DNA encoding human 5-HT3-C has been cloned and characterized. The recombinant protein is capable of forming biologically active human 5-HT3-C protein. The cDNA has been expressed in recombinant host cells that produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Un ADN codant la 5-HT3-C humaine a été cloné et caractérisé. La protéine recombinée est capable de former une protéine bioactive humaine de 5-HT3-C. L'ADNc a été exprimé dans des cellules hôtes recombinées produisant des protéines recombinées actives. De plus, les cellules hôtes recombinées sont utilisées pour établir une méthode d'identification de modulateurs de l'activité du récepteur, et des modulateurs du récepteur sont identifiés.
Buehler Lukas K.
Dubin Adrienne E.
Erlander Mark G.
Huvar Arne
Huvar Rene
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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