Dna encoding a human subunit of the 5-ht3 serotonin receptor

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 1/00 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C12N 1/20 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2374432

DNA encoding human 5-HT3-B has been cloned and characterized. The recombinant protein is capable of forming biologically active human 5-HT3-B protein. The cDNA has been expressed in recombinant host cells that produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

Cette invention concerne un ADN qui code le 5-HT3-B et qui a été cloné et caractérisé. La protéine recombinante est capable de former une protéine de 5-HT3-B humaine et bioactive. L'ADNc a été exprimé dans des cellules hôtes recombinantes qui produisent une protéine recombinante active. En outre, les cellules hôtes recombinantes ont été utilisées afin d'élaborer un procédé permettant d'identifier les modulateurs de l'activité du récepteur, et des modulateurs du récepteur ont été identifiés.

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