Dna encoding bradykinin b1 receptor

Details Dna encoding bradykinin b1 receptor Dna encoding bradykinin b1 receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2187740

DNAs encoding bradykinin B1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind des-Arg10kallidin and other B1-specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

On a cloné et caractérisé des ADN codant des récepteurs B¿1? de bradykinine de cellules de mammifères. Le récepteur recombinant peut former des récepteurs se fixant à des-Arg?10¿kallidine et à d'autres ligands spécifiques de B¿1?. L'ADN a été exprimé dans des cellules hôtes recombinantes qui produisent une protéine recombinante active. De plus, on utilise les cellules hôtes recombinantes pour établir un procédé d'identification de modulateurs de l'activité du récepteur et on identifie les modulateurs du récepteur.

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