Dna encoding cai resistance proteins and uses thereof

Details Dna encoding cai resistance proteins and uses thereof Dna encoding cai resistance proteins and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/52 (2006.01) G01N 33/53 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2185341

This invention provides for nucleotide sequences that encode CAIR proteins correlated with cellular resistance to carboxyamido- triazole (CAI) and functionally equivalent compounds. The invention further provides for methods of detecting CAI resistance in biological samples and for cell lines that grow and proliferate in the presence of CAI and functionally equivalent compounds.

Cette invention concerne des séquences nucléotidiques qui codent des protéines de résistance au CAI (CAIR) ayant une corrélation avec une résistance cellulaire au carboxyamido-triazole (CAI) et des composés de fonctionnalité équivalente. Cette invention concerne également des procédés de détection de la résistance au CAI dans des échantillons biologiques, et des lignées cellulaires qui se développent et prolifèrent en présence de CAI et de composés de fonctionnalité équivalente.

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