Dna encoding canine von willebrand factor and methods of use

Details Dna encoding canine von willebrand factor and methods of use Dna encoding canine von willebrand factor and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/755 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2261015

The complete sequence of the canine von Willebrand Factor cDNA and deduced amino acid sequence is provided. The mutation which causes von Willebrand's Disease in Scottish Terriers, a single base deletion in exon 4, has also been determined. Methods for detecting carriers of the defective vWF gene are also provided.

Cette invention concerne la séquence complète de l'ADN complémentaire du facteur canin de Von Willebrand ainsi que la séquence aminoacide déduite. Elle concerne notamment la mutation qui provoque la maladie de Von Willebrand chez les terriers écossais, une délétion de base unique dans l'exon 4. L'invention se rapporte également à des procédés de détection de porteurs du gène défectueux du facteur de Von Willebrand.

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