Dna encoding galanin galr3 receptors and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/16 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/22 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2248222

This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

La présente invention concerne un acide nucléique isolé codant un récepteur de galanine de mammifère, une protéine isolée récepteur de galanine, des vecteurs comprenant un acide nucléique isolé codant un récepteur de galanine de mammifère, des cellules comprenant de tels vecteurs, des anticorps dirigés contre un récepteur de galanine de mammifère, des sondes d'acide nucléique servant à détecter un acide nucléique codant un récepteur de galanine de mammifère, des oligonucléotides antisens complémentaires de séquences uniques d'acide nucléique codant un récepteur de galanine de mammifère, des animaux transgéniques non humains exprimant un ADN codant un récepteur de galanine d'un mammifère normal ou mutant, ainsi que des procédés permettant de déterminer la liaison de composés à des récepteurs de galanine de mammifère.

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