Dna encoding glutamate gated chloride channels

Details Dna encoding glutamate gated chloride channels Dna encoding glutamate gated chloride channels

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2220116

DNA encoding glutamate and avermectin-sensitive chloride channels have been cloned and characterized. The protein is capable of forming channels selectively opened with either avermectin or glutamate. The cDNA has been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified. Receptor modulators active in the method disclosed herein are useful as ectoparasiticides, antiparasitic, anthelmenthic, acaracidal and insecticide agents.

On a cloné et caractérisé l'ADN codant les canaux à chlorure sensibles au glutamate et à l'avermectine. La protéine est capable de former des canaux ouverts sélectivement par de l'avermectine ou du glutamate. L'ADNc a été exprimé dans des cellules hôtes de recombinaison qui produisent la protéine de recombinaison active. La protéine de recombinaison est également purifiée à partir des cellules hôtes de recombinaison. En outre, on utilise lesdites cellules hôtes de recombinaison pour mettre en oeuvre une méthode d'identification des modulateurs de l'activité des récepteurs, et les modulateurs des récepteurs sont identifiés. Les modulateurs des récepteurs actifs selon l'invention sont utiles en tant qu'agents ectoparasiticides, antiparasitaires, anthelminthiques, acaricides et insecticides.

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