Dna encoding human 5-ht1d receptors and uses thereof

Details Dna encoding human 5-ht1d receptors and uses thereof Dna encoding human 5-ht1d receptors and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2082390

This invention provides isolated nucleic acid molecules encoding human 5-HT 1D receptors, isolated proteins which are human 5-HT 1D receptors, vectors comprising isolated nucleic acid molecules encoding human 5-HT 1D receptors, mammal- ian cells comprising such vectors, antibodies directed to the human 5-HT 1D receptors, nucleic acid probes useful for detect- ing nucleic acid encoding human 5-HT 1D receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human 5-HT 1D p receptor, pharmaceutical compounds related to human 5-HT 1D p receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human 5- HT 1D receptor. This invention fur- ther provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the hu- man 5-HT 1D receptor.

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