Dna encoding human 5-ht1d receptors and uses thereof

Details Dna encoding human 5-ht1d receptors and uses thereof Dna encoding human 5-ht1d receptors and uses thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2374571

This invention provides isolated nucleic acid molecules encoding 5-HT1D receptors, isolated proteins which are human 5-HT1D receptors, vectors comprising nucleic acid molecules encoding human 5-HT1D receptors, mammalian cells comprising such vectors, antibodies directed to the human 5-HT1D receptors, nucleic acid probes useful for detecting nucleic acid encoding human 5-HT1D receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human 5-HT1D receptor, pharmaceutical compounds related to human 5-HT1D receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human 5-HT1D receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening and treatment involving the human 5-HT1D receptor.

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