Dna encoding human alpha 1 adrenergic receptors and uses...

Details Dna encoding human alpha 1 adrenergic receptors and uses... Dna encoding human alpha 1 adrenergic receptors and uses...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2145182

This invention provides an isolated nucleic acid, vectors, transformed mammalian cells and non-human transgenic animals that encode and express normal or mutant alpha 1a, alpha 1b and alpha 1c adrenergic receptor genes. This invention also pro- vides a protein, antibody directed to the protein and pharmaceutical compounds related to alpha 1a, alpha 1b and alpha 1c ad- renergic receptors. This invention provides nucleic acid probe, antisense oligonucleotide complementary to alpha 1a, alpha 1b and alpha 1c adrenergic receptor genes. This invention further provides methods for determining ligand binding, detecting ex- pression, drug screening, and treatments for alleviating abnormalities associated with human alpha 1a, alpha 1b and alpha 1c ad- renergic receptors.

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