C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C07K 14/705 (2006.01) C12N 5/18 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2427676
Isolated nucleic acid molecules, i.e., DNA or RNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing .alpha. and .beta. subunits and recombinant (i.e., isolated or substantially pure) .alpha. subunits and .beta. subunits are provided. In addition, cells expressing various multimeric combinations of subunits (i.e., .alpha.1 .alpha.2 .alpha.3 .alpha.4 .alpha.5 a6 and/or .alpha.7 in combination with at least one of an .alpha. and .beta. subunit are also provided. A recombinant, non-human cell line expressing the human .alpha.7 subunit of nAChR is also disclosed.
La présente invention concerne des molécules d'acide nucléique isolées, c'est-à-dire un ADN ou un ARN codant pour des sous-unités alpha et bêta du récepteur nicotinique neuronal de l'acétylcholine, des cellules amphibiennes et mammifères contenant ledit ADN, des méthodes permettant de produire des sous-unités alpha et bêta et des sous-unités de recombinaison (c'est-à-dire isolées ou essentiellement pures) alpha et bêta. En outre, l'invention concerne des cellules exprimant diverses combinaisons multimériques de sous-unités (c'est-à-dire, alpha1, alpha2, alpha3, alpha4, alpha5, alpha6 et/ou alpha7 en combinaison avec au moins une des sous-unités alpha et bêta. La présente invention concerne une lignée cellulaire de recombinaison non humaine exprimant la sous-unité alpha7 humaine du nAChR.
Chavez-Noriega Laura Elena
Claeps Brian O.
Elliott Kathryn J.
Gillespie Alison
Siegel Robert
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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