Dna encoding human vanilloid receptor vr3

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C07K 16/26 (2006.01) C12N 5/10 (2006.01) C12N 15/16 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2400299

DNA encoding human VR1 receptor has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

Selon l'invention, un ADN codant pour le récepteur VR1 humain a été cloné et caractérisé. La protéine de recombinaison est capable de former une protéine biologiquement active. Les ADNc ont été exprimés dans des cellules hôtes de recombinaison qui produisent la protéine de recombinaison active. Ladite protéine de recombinaison est également purifiée à partir des cellules hôtes de recombinaison. De plus, les cellules hôtes de recombinaison sont utilisées pour élaborer une méthode d'identification de modulateurs de l'activité de récepteur, et des modulateurs de récepteur ont été identifiés.

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