Dna encoding mammalian phosphodiesterases

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/55 (2006.01) A61K 39/395 (2006.01) C12N 1/19 (2006.01) C12N 9/16 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/44 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2085881

The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDes). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.

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