C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 39/395 (2006.01) C12N 1/19 (2006.01) C12N 9/16 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/44 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2085881
The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDes). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
Beavo Joseph A.
Bentley J. Kelley
Charbonneau Harry
Sonnenburg William K.
Smart & Biggar
The Board Of Regents Of The University Of Washington
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