Dna encoding neospora dihydrofolate reductase-thymidylate...

Details Dna encoding neospora dihydrofolate reductase-thymidylate... Dna encoding neospora dihydrofolate reductase-thymidylate...

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) A61K 39/012 (2006.01) C07K 14/44 (2006.01) C07K 16/40 (2006.01) C12N 1/11 (2006.01) C12N 1/36 (2006.01) C12N 9/00 (2006.01) C12N 9/06 (2006.01) C12N 9/10 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2253011

The present invention provides isolated polynucleotide molecules comprising a nucleotide sequence encoding the DHFR-TS protein of Neospora which polynucleotide molecules are useful in preparing modified live vaccines against neosporosis, and as diagnostic reagents. The present invention further provides cloning and and expression vectors, transformed host cells substantially purified DHFR-TS proteins and peptide fragments, genetic constructs useful for targeted gene deletion, and vaccine compositions.

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