C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 39/012 (2006.01) A61K 48/00 (2006.01) A61P 33/02 (2006.01) C07K 14/445 (2006.01) C07K 14/455 (2006.01) C07K 16/20 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 15/30 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2471145
The present invention relates to novel protozoal cyclic GMP dependent protein kinases and genes encoding same that have been isolated from Eimeria maxima and Plasmodium falciparum. Nucleic acid molecules having sequences that encode such proteins as well as antibodies raised against such proteins are also disclosed. These enzymes may be used in screening assays to identify potential antiprotozoal agents. As well, methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitor are also provided as are therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites such as Eimeria maxima and Plasmodium falciparum.
L'invention concerne de nouvelles protéine kinase protozoaires dépendantes de la GMP cyclique ainsi que les gènes codant pour ces protéines kinases, isolés à partir de Eimeria maxima et de Plasmodium falciparum. L'invention concerne également des molécules d'acide nucléique qui contiennent des séquences codant pour ces protéines, ainsi que des anticorps dirigés contre ces protéine. Ces enzymes peuvent être utilisées dans des méthodes de criblage, destinées à identifier des agents antiprotozoaires potentiels. L'invention concerne en outre des procédés permettant d'obtenir de ces molécules d'acide nucléique, protéines, anticorps et inhibiteurs, ainsi que des compositions thérapeutiques contenant ces molécules d'acide nucléique, protéines, anticorps et inhibiteurs, et l'utilisation de ceux-ci pour protéger les animaux contre les maladies causées par des parasites tels que Eimeria maxima et Plasmodium falciparum.
Diaz Carmen
Gurnett Anne
Liberator Paul
Schmatz Dennis
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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