Dna encoding precursor interleukin 1beta converting enzyme

Details Dna encoding precursor interleukin 1beta converting enzyme Dna encoding precursor interleukin 1beta converting enzyme

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C12N 1/21 (2006.01) C12N 9/64 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2076159

Complementary DNA (cDNA) encoding the precursor interleukin-1.beta. (pre-IL-1.beta.) converting enzyme (ICE) is isolated from a cDNA library. A cDNA, encoding the full-length open reading frame (ORF) for the nascent ICE, as well as individual cDNAs encoding the 20 kDa subunit and the 10 kDa subunit of ICE are identified and sequenced. ICE is useful in the conversion of pre-IL-1.beta. into mature IL-1.beta.. The recombinantly produced ICE, including the individual 20 kDa and 10 kDa subunits is useful in the diagnosis of inflammatory diseases, in the production of recombinant IL-1.beta., and to identify inhibitors of ICE activity.

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