Dna encoding rat bombesin receptor subtype-3 (brs-3) and...

Details Dna encoding rat bombesin receptor subtype-3 (brs-3) and... Dna encoding rat bombesin receptor subtype-3 (brs-3) and...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2456857

A rat bombesin receptor subtype-3 has been isolated, cloned and sequenced. This receptor is characteristic of the G-protein family of receptors. Isolation of rat bombesin receptor subtype-3 may be used to screen and identify novel bombesin receptor modulators that may contribute to the regulation of endocrine processes, metabolism, or the cell cycle. Such compounds may be used in the treatment of conditions that result from deregulated expression of bombesin receptor subtype-3.

L'invention concerne un sous-type 3 de récepteur de la bombésine du rat isolé, cloné et séquencé. Ledit récepteur caractérise la famille des récepteurs de la protéine G. On peut utiliser l'isolation du sous-type 3 de récepteur de la bombésine du rat pour cribler et identifier de nouveaux modulateurs de récepteurs de la bombésine pouvant participer à la régulation de processus endocrinaux, du métabolisme, ou du cycle cellulaire. On peut utiliser ces composés pour traiter des états résultant d'une expression dérégulée du sous-type 3 de récepteur de la bombésine.

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