Dna encoding the beta subunit of a mammalian "maxi-k"...

Details Dna encoding the beta subunit of a mammalian "maxi-k"... Dna encoding the beta subunit of a mammalian "maxi-k"...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2189761

This invention relates to heteromultimer and its use in screening pharmaceutically active compounds for modulators of maxi-K channel activity. Such modulators are useful in treating asthma, pregnant human myometrium, hypertension and angina, cerebral ischemia and in conditions where stimulation of neurotransmitter release is desired such as Alzheimer's disease and stimulation of damaged nerves.

Cette invention se rapporte à un hétéromultimère et à son utilisation dans le criblage de composés pharmaceutiquement actifs destinés à des modulateurs de l'activité du canal maxi-K. Ces modulateurs sont utilisés dans le traitement de l'asthme, du myomètre de la femme enceinte, de l'hypertension et de l'angine, de l'ischémie cérébrale et dans des états où la stimulation de la libération des neurotransmetteurs est souhaitée, telles que la maladie d'Alzheimer, ainsi que la stimulation des nerfs endommagés.

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