Dna encoding the human serine protease c-e

Details Dna encoding the human serine protease c-e Dna encoding the human serine protease c-e

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/48 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 15/57 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) C12N 15/79 (2006.01) C12N 15/866 (2006.01) C12Q 1/37 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2382953

Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and its alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease C-E mRNA is expressed in pancreas, placenta, prostate, small intestine, stomach, spleen, fibroblasts and epidermis, as well as in certain regions of the brain i.e., cerebellum, cerebral cortex, pituitary and hippocampus. Enzymatically active protease C-E, as produced using the methodologies described herein, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.

L'invention concerne l'identification moléculaire d'un ADNc codant une nouvelle sérine protéase que nous avons appelée protéase C-E. La séquence d'acides aminées déduite, et son alignement avec d'autres sérine protéases bien caractérisées, indiquent que la protéase identifiée appartient à la famille des sérine protéases S1. Nous avons découvert que l'ARNm de la protéase C-E est exprimé dans le pancréas, le placenta, la prostate, l'intestin grêle, l'estomac, la rate, les fibroblastes et l'épiderme, ainsi que dans certaines régions du cerveau, à savoir le cervelet, le cortex cérébral, l'hypophyse et l'hippocampe. La protéase C-E à activité enzymatique, telle que produite à l'aide des techniques selon l'invention, peut faire l'objet d'autres analyses biochimiques axées sur l'identification de substrats physiologiques et de modulateurs spécifiques.

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