Dna encoding the human vanilloid receptor vr1

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01N 37/18 (2006.01) A61K 38/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 17/00 (2006.01) C12N 1/20 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12P 21/04 (2006.01) C12P 21/06 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2370570

DNA encoding human VR1 receptor has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

Dans cette invention, on a cloné et caractérisé l'ADN codant les récepteurs humains des vanilloïdes VR1. La protéine recombinante est capable de former une protéine biologiquement active. Les ADNc ont été exprimés dans des cellules hôtes recombinantes qui produisent la protéine active recombinante. La protéine recombinante est également purifiée à partir des cellules hôtes recombinantes. En outre, les cellules hôtes recombinantes sont utilisées pour mettre en oeuvre un procédé destiné à identifier les modulateurs de l'activité du récepteur, et l'on identifie les modulateurs du récepteur.

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