Dna encoding the prostate-specific membrane antigen-like...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2370033

The present invention discloses a new gene, termed PSMA-like, that is very similar to the prostate-specific membrane antigen (PSMA) gene and cross-reacts with current detection methods for PSMA. The present invention also provides for a method of distinguishing the PSMA and PSMA-like mRNAs and/or proteins for diagnostic and therapeutic strategies that desire specific targeting of either the PSMA or PSMA-like gene.

La présente invention concerne un nouveau gène, appelé <= de type PSMA >=, lequel gène est très semblable au gène de l'antigène membranaire spécifique de la prostate (PSMA) et réagit de manière croisée avec les méthodes de détection de l'antigène membranaire spécifique de la prostate qui sont actuellement en cours. La présente invention concerne également une méthode permettant de distinguer les ARN messagers du PSMA ou du type PSMA et/ou les protéines, laquelle méthode est utile aux stratégies thérapeutiques et diagnostiques nécessitant un ciblage spécifique du gène du PSMA ou du gène de type PSMA.

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