Dna encoding the vertebrate homolog of hedgehog, vhh-1,...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/18 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/46 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2184092

This invention provides an isolated nucleic acid molecule encoding a vhh-1 protein, an isolated protein which is a vhh-1 protein, vectors comprising an isolated nucleic acid molecule encoding a vhh-1 protein, mammalian cells comprising such vectors, antibodies directed to a vhh-1 protein, nucleic acid probes useful for detecting a nucleic acid molecule encoding a vhh-1 protein, pharmaceutical compositions related to the vhh-1 proteins, nonhuman transgenic animals which express a normal or a mutant vhh-1 protein. This invention further provides methods for inducing differentiation of floor plate cell, motor neuron, generating ventral neurons and treatments for alleviating abnormalities associated with the vhh-1 protein.

L'invention concerne une molécule d'acide nucléique qui a été isolée et qui code une protéine vhh-1, une protéine isolée qui est une protéine vhh-1, des vecteurs comprenant une molécule d'acide nucléique isolée qui code une protéine vhh-1, des cellules de mammifères qui comprennent de tels vecteurs, des anticorps dirigés contre une protéine vhh-1, des sondes à acide nucléique permettant de détecter une molécule d'acide nucléique codant une protéine vhh-1, des compositions pharmaceutiques relatives aux protéines vhh-1, et des animaux transgéniques qui expriment une protéine vhh-1 normale ou mutante. Cette invention concerne aussi des procédés permettant d'induire une différenciation entre des cellules de base et des neurones moteurs et de créer de neurones ventraux, et elle concerne des traitements permettant d'atténuer des anomalies assoicées à la protéine vhh-1.

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