Dna immunization against chlamydia infection

A - Human Necessities – 61 – K

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Details

A61K 48/00 (2006.01) A61K 31/70 (2006.01) C07K 14/295 (2006.01)

Patent

CA 2259595

Nucleic acid, including DNA, immunization to generate a protective immune response in a host, including humans, to a major outer membrane protein of a strain of Chlamydia, preferably contains a nucleotide sequence encoding a MOMP or a MOMP fragment that generates antibodies that specifically react with MOMP and a promoter sequence operatively coupled to the first nucleotide sequence for expression of the MOMP in the host. The non-replicating vector may be formulated with a pharmaceutically-acceptable carrier for in vivo administration to the host.

Immunisation à l'acide nucléique, y compris à l'ADN, pour générer une réponse immunitaire chez un hôte, dont l'homme, à une protéine majeure de membrane externe (MOMP) d'une souche de Chlamydia. La composition de la présente invention contient de préférence une séquence nucléotidique codant une MOMP ou un fragment de MOMP qui génère des anticorps réagissant spécifiquement avec la MOMP et une séquence de promoteur liée de manière opérationnelle à la première séquence de nucléotide en vue de l'expression de la MOMP dans l'hôte. Le vecteur non-réplicant peut être formulé avec un excipient pharmaceutiquement acceptable en vue de l'administration in vivo à un hôte.

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