C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2670082
The present invention provides methods for identifying metastases by detecting nucleic acid hypermethylation of one or more genes in one or more samples, and in particular in the lymph nodes. The invention further relates to DNA methylation as a predictor of disease recurrence and patient prognosis, specifically in the field of cancer biology.
La présente invention concerne des méthodes d'identification de métastases par détection d'une hyperméthylation d'acide nucléique d'un ou plusieurs gènes dans un ou plusieurs échantillons, et notamment dans les noeuds lymphatiques. L'invention concerne également l'utilisation de la méthylation de l'ADN comme prédicteur de la récurrence d'une maladie et pour le pronostic de patients, notamment dans le domaine de la biologie du cancer.
Baylin Stephen
Brock Malcolm V.
Herman James G.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Johns Hopkins University
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