Dna molecule encoding for cellular uptake of mycobacterium...

A - Human Necessities – 61 – K

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Details

A61K 39/00 (2006.01) C07H 19/00 (2006.01) C07H 21/04 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2284514

The present invention relates to DNA molecules associated with conferring on Mycobacterium tuberculosis an ability to enter mammalian cells. The protein encoded by these DNA molecules are useful in vaccines to prevent infection by Mycobacterium tuberculosis, while the antibodies raised against this protein can be employed in passively immunizing those already infected by the organism. Both these proteins and antibodies may be utilized in diagnostic assays to detect Mycobacterium tuberculosis in tissue or bodily fluids. The protein of the present invention can be associated with various other therapeutic materials, for administration to mammals, particularly humans, to achieve uptake of those materials by such cells.

La présente invention concerne des molécules d'ADN qui interviennent pour conférer à Mycobacterium tuberculosis la capacité de pénétrer dans les cellules de mammifère. La protéine codée par ces molécules d'ADN est utilisée dans des vaccins destinés à prévenir l'infection par Mycobacterium tuberculosis, et les anticorps mobilisés contre cette protéine peuvent être utilisés pour l'immunisation passive des personnes déjà infectées par l'organisme. Ces protéines et ces anticorps peuvent être utilisés dans des méthodes diagnostiques permettant de déceler Mycobacterium tuberculosis dans les tissus ou les fluides corporels. La protéine de la présente invention peut être associée à diverses autres substances thérapeutiques et être administrée à des mammifères, en particulier des êtres humains, afin que ces substances soient absorbées par les cellules.

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