Dna molecules

Details Dna molecules Dna molecules

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07K 14/35 (2006.01) C12N 1/21 (2006.01) C12N 9/12 (2006.01) C12N 15/70 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2171600

The present invention provides novel nucleic acid molecules coding for sigma subunits of Mycobacterium tuberculosis RNA polymerase. It also relates to polypeptides, referred to as SigA and SigB, encoded by such nucleic acid molecules, as well as to vectors and host cells transformed with the said nucleic acid molecules. The invention further provides screening assays for compounds which inhibit the interaction between a sigma subunit and a core RNA polymerase.

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