C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12P 21/06 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2401852
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Drosophila melanogaster ligand-gated ion channel proteins. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding Drosophila ligand- gated ion channel proteins, substantially purified forms of associated Drosophila ligand-gated ion channel proteins and recombinant membrane fractions comprising these proteins, associated mutant proteins, and methods associated with identifying compounds which modulate associated Drosophila melanogaster ligand-gated ion channel proteins, which will be useful as insecticides.
La présente invention concerne pour partie des molécules d'acide nucléiques isolées (des polynucléotides) qui codent des protéines du canal ionique borné de ligand de Drosophila melanogaster. La présente invention concerne des vecteurs de recombinaison et des hôtes de recombinaison qui contiennent un fragment d'ADN codant des protéines du canal ionique borné de ligand de Drosophila, des formes sensiblement purifiées des protéines associées du canal ionique borné de ligand de Drosophila, et des fractions de membrane de recombinaison comprenant ces protéines, des protéines mutantes associées, et des procédés associés à l'identification de composés modulant les protéines associées du canal ionique borné de ligand de Drosophila melanogaster, qui conviennent vraisemblablement comme insecticides.
Cully Doris F.
Hirschberg Birgit
Yuan Jeffrey
Zheng Yingcong
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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