Dna molecules encoding human clax proteins and their soluble...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2368548

Isolated novel cDNA sequences encoding a human C-type lectin and three homologues are provided. They are referred to herein as "CLAX" (C-type Lectin, Activation Expressed) proteins. The invention also includes methods of using the nucleic acid sequences, polypeptides encoded by the nucleic acid sequences disclosed herein, fusion proteins having all or a portion (e.g., an extracellular region) of the CLAX proteins, antibodies specific for the novel CLAXs, ligands and inhibitors for the novel CLAXs. The genes of CLAX are specifically expressed in lymphoid tissues and activated T lymphocytes but not resting T lymphocytes. The invention concers the utility in pharmaceutical compositions for the prevention and treatment of infectious, inflammatory and allergic diseases.

L'invention concerne de nouvelles séquences d'ADNc isolées codant pour une lectine de type C humaine et trois homologues, qui sont appelées ici protéines "CLAX" (lectine de type C à activation exprimée). L'invention concerne également des procédés d'utilisation des séquences d'acides nucléiques, des polypeptides codés par les séquences d'acides nucléiques décrites, des protéines de fusion comportant tout ou partie (p. ex. une région extracellulaire) des protéines CLAX, des anticorps spécifiques des nouvelles protéines CLAX, des ligands et des inhibiteurs des nouvelles protéines CLAX. Les gènes de CLAX sont exprimés spécifiquement dans des tissus lymphoïdes et dans des lymphocytes T activés, mais pas dans les lymphocytes T au repos. L'invention concerne l'utilisation de ces protéines dans des compositions pharmaceutiques servant à prévenir et à traiter des maladies infectieuses, inflammatoires et allergiques.

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