C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 5/10 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12P 21/06 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2405268
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Rhipicephalus sanguineus glutamate gated chloride channels. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding R. sanguineus glutamate gated chloride channels, substantially purified forms of associatedR. sanguineus glutamate gated chloride channels and recombinant membrane fractions comprising these proteins, associated mutant proteins, and methods associated with identifying compounds which modulate associated Rhipicephalus sanguineus glutamate gated chloride channels, which will be useful as insecticides.
La présente invention concerne, en partie, des molécules d'acides nucléiques isolées (polynucléotides) codant des canaux à chlorure activés par le L-glutamate de <i>Rhipicephalus sanguineus</i>. Cette invention concerne également des vecteurs recombinants et des hôtes recombinants qui contiennent un fragment d'ADN codant des canaux à chlorure activés par le L-glutamate de <i>R. sanguineus</i>, des formes pratiquement purifiées de canaux associés à des canaux à chlorure activés par le L-glutamate de <i>R. sanguineus</i> et des fractions de membranes recombinantes renfermant ces protéines, des protéines mutantes associées, et des méthodes associées à l'identification de composés modulant des canaux à chlorure activés par le L-glutamate de <i>R. sanguineus</i> utilisés comme insecticides.
Cully Doris F.
Hamelin Michel J.
Warmke Jeffrey W.
Yang Youfeng
Merck & Co. Inc.
Merial Limited
Smart & Biggar
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