C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2388162
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Schistocerca americana (grasshopper) glutamate- gated chloride channels. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding S. americana glutamate-gated chloride channels, substantially purified forms of associated S. americana glutamate-gated chloride channels and recombinant membrane fractions comprising these proteins, associated mutant proteins, and methods associated with identifying compounds which modulate associated Schistocerca americana glutamate-gated chloride channels, which will be useful as insecticides.
La présente invention concerne, en partie, des molécules d'acides nucléiques isolées (polynucléotides) qui codent des canaux à chlorure activés par le glutamate de Schistocerca americana (sauterelle). Cette invention a également trait à des vecteurs recombinants et des hôtes recombinants qui contiennent un fragment d'ADN codant des canaux à chlorure activés par le glutamate deS. americana, des formes pratiquement purifiées de canaux associés à chlorure activés par le glutamate de S. americana et des fractions de membranes recombinantes renfermant ces protéines, des protéines mutantes associées et des méthodes liées à des composés d'identification qui modulent des canaux à chlorure activés par le glutamate de S. americana utilisés comme insecticides.
Hamelin Michel J.
Warmke Jeffrey W.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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