Dna probe diffraction assay and reagents

Details Dna probe diffraction assay and reagents Dna probe diffraction assay and reagents

C - Chemistry, Metallurgy

12

Q

73/53, 204/91.11

C12Q 1/68 (2006.01) G01N 21/77 (2006.01) G01N 33/543 (2006.01)

Patent

CA 1339117

The invention provides a biograting for use in determining the amount of an analyte in a sample in a light diffraction assay. The biograting has a smooth, solid surface that reduces nonspecific binding, thereby providing better resolution than in prior art systems. A process for manufacturing the biograting comprises adhering a uniform layer of hybridizing reagent on the smooth, solid surface and exposing the surface to UV radiation through a shadow mask with diffraction grating lines to selectively deactivate the hybridizing reagent. This process produces a biological diffraction grating design of lines of active hybridizing reagent. The invention includes a biograting wherein the hybridizing reagent is a nucleotide sequence. This biograting is used to detect a specific DNA sequence in a diffraction hybridizing assay.

605154

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