Dna & protein binding miniature proteins

Details Dna & protein binding miniature proteins Dna & protein binding miniature proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/00 (2006.01) C07K 14/465 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2407377

The present invention provides a protein scaffold, such as an avian pancreatic polypeptide, that can be modified by substitution of two or more amino acid residues that are exposed on the alpha helix domain of the polypeptide when the polypeptide is in a tertiary form.

La présente invention se rapporte à un échafaudage protéique, tel qu'un polypeptide pancréatique, qui peut être modifié par substitution d'au moins deux restes d'acides aminés qui sont exposés sur le domaine d'hélice alpha du polypeptide lorsque ce dernier se présente sous une forme tertiaire.

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