C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) C07H 21/00 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2182561
The present invention provides oligonucleotides sequences comprising DNA regulatory elements comprising point mutations of Ly6E GAS element that bind activated transcriptional proteins in response to signaling molecules, such as cytokines. Further, the present invention also provides DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, and methods of using the DNA constructs and transfected cells to provide for the controlled expression of structural genes, for the detection and recovery of transcriptional regulatory proteins, and for measuring the ability of compounds to act as agonists and antagonists of gene transcription.
Séquences d'oligonucléotides comprenant des éléments régulateurs d'ADN comprenant des mutations ponctuelles de l'élément Ly6E GAS qui lient des protéines régulatrices transcriptionnelles activées en réponse à des molécules de signalisation telles que des cytokines. Cette invention concerne également des structures d'ADN comprenant les séquences d'oligonucléotides, des cellules transfectées avec les structures d'ADN et des procédés d'utilisation desdites structures d'ADN et des cellules transfectées pour assurer l'expression régulée de gènes de structure, pour détecter et récupérer des protéines régulatrices de transcription et pour mesurer la capacité de composés à agir comme agonistes ou antagonistes de la transcription génique.
Lamb I. Peter
Seidel H. Martin
Lamb I. Peter
Ligand Pharmaceuticals Inc.
Seidel H. Martin
Sim & Mcburney
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