Dna sequence and recombinant production of the grass pollen...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/29 (2006.01) A61K 38/16 (2006.01) A61K 39/35 (2006.01) A61K 39/36 (2006.01) A61K 48/00 (2006.01) A61P 37/08 (2006.01) C07K 14/415 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2491038

The invention relates to the provision of the gene sequence of the grass pollen main allergen Phl p 4. The invention also includes fragments, novel combinations of partial sequences and point mutants having a hypoallergenic effect. The recombinant DNA molecules and the derived polypeptides, fragments, novel combinations of partial sequences and variants can be used for the therapy of pollen-allergy diseases. The recombinantly produced proteins can be used for <i>in vitro</i> and <i>in vivo</i> diagnosis of pollen allergies.

L'invention se rapporte à la préparation de la séquence génique de l'allergène principal des pollens de plantes herbacées Phl p4. Cette invention concerne en outre des fragments, de nouvelles combinaisons de séquences partielles ainsi que des mutants ponctuels présentant une action hypoallergénique. Les molécules d'ADN recombinées ainsi que les polypeptides, fragments, nouvelles combinaisons de séquences partielles et variants qui en découlent peuvent être utilisés pour traiter des maladies allergiques liées aux pollens. Les protéines produites de manière recombinée peuvent être employées pour effectuer un diagnostic in vitro ou in vivo d'allergies aux pollens.

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