Dna sequences encoding cmh-1, a cysteine protease involved...

Details Dna sequences encoding cmh-1, a cysteine protease involved... Dna sequences encoding cmh-1, a cysteine protease involved...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2235623

The invention relates to DNA sequences encoding both active and inactive forms of CMH-1, a cysteine protease involved in programmed cell death. The invention further relates to the polypeptides encoded by those DNA sequences and antibodies to those polypeptides. The invention also relates to recombinant DNA molecules comprising these DNA sequences, as well as hosts transformed with such recombinant DNA molecules. The invention further relates to the use of the DNA sequences of this invention in gene therapy for both promoting and inhibiting apoptosis. The DNA sequences of this invention are also useful in diagnosing cells which have the potential to undergo apoptosis. Finally, the polypeptides encoded by the DNA sequences of this invention are useful in identifying inhibitors of apoptosis.

L'invention porte sur des séquences d'ADN codant à la fois des formes actives et inactives de la CMH-1, une cystéine protéase impliquée dans la mort cellulaire programmée. L'invention porte également sur les polypeptides codés par lesdites séquences d'ADN et sur les anticorps contre ces polypeptides. Elle porte également sur des molécules d'ADN de recombinaison comprenant les susdites séquences d'ADN ainsi que sur des hôtes transformés au moyen desdites molécules d'ADN de recombinaison. L'invention porte en outre sur l'utilisation des séquences d'ADN de l'invention en thérapie génique pour promouvoir ou au contraire inhiber l'apoptose. Les séquences d'ADN de l'invention peuvent également servir à diagnostiquer les cellules susceptibles d'apoptose. Les polypeptides codés par lesdites séquences d'ADN de l'invention servent également à identifier des inhibiteurs de l'apoptose.

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