C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/17 (2006.01) C07K 14/62 (2006.01) C12N 1/15 (2006.01) C12N 15/80 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2155451
The present invention relates to DNA sequences encoding insulin precursors of formula B-Pg-A, wherein B and A represent B- and A-chains, respectively, and Pg represents modified C-peptide or any number of amino acids comprising at least one glycosylation consensus site. The invention also relates to a process for the preparation of insulin by culturing suitable cells, preferably fungal cells, transformed with a vector comprising DNA sequence encoding insulin precursor of given formula. The invention further relates to DNA sequences encoding pharmaceutical peptides and proteins in which N-glycosylation consensus site is introduced in a non-essential site in any spacer region for higher expression and secretion of proteins.
Mestric Silvija
Punt Peter J.
Valinger Radovan
Van Den Hondel Cees A.m.j.j.
Borden Ladner Gervais Llp
Dion Icko Drustvo Pliva Farmaceutska Kemijska Prehrambena I. Kozmeticka Industrija
Mestric Silvija
Punt Peter J.
Valinger Radovan
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