C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/09 (2006.01) A61K 39/40 (2006.01) C07H 21/00 (2006.01) C07K 14/315 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2105057
The invention provides DNA sequences which code for polypeptides which are characteristic for the virulence of the pathogenic bacterium Streptococcus suis and parts thereof, and polypeptides and antibodies derived therefrom. The sequences code for a polypeptide of 90.000-120.000 daltons or a polypeptide of higher molecular weight containing such a polypeptide, and for a polypeptide of 135.000-136.000 daltons (muramidase released protein), or parts thereof. The sequences themselves, and also the polypeptides and antibodies derived therefrom, are used for diagnosis of and protection against infection by S. suis in mammals, including man.
Séquences d'ADN codant pour des polypeptides caractéristiques de la virulence de la bactérie pathogène Streptococcus suis et de parties de celle-ci, et polypeptides et anticorps dérivés de celles-ci. Lesdites séquences codent pour un polypeptide présentant de 90'000 à 120'000 daltons ou pour un polypeptide à poids moléculaire plus élevé contenant un tel polypeptide, ainsi que pour un polypeptide présentant de 135'000 à 136'000 daltons (protéine libérée par muramidase), ou pour des parties de celui-ci. Les séquences proprement dites, ainsi que les polypeptides et anticorps dérivés de celles-ci, servent au diagnostic et à la prophylaxie de l'infection par S. suis chez les mammifères, y compris l'homme.
Smith Hilda E.
Vecht Uri
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Vetoquinol
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