C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2165057
The present invention provides oligonucleotide sequences comprising DNA regulatory elements of the general sequence TTNXAA that bind activated transcriptional regulatory proteins in response to signaling molecules, such as cytokines. Further, the present invention also provides DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, and methods of using the DNA constructs and transfected cells to provide for the controlled expression of structural genes, for the detection and recovery of transcriptional regulatory proteins, and for measuring the ability of compounds to act as agonists and antagonists of gene transcription.
Séquences d'oligonucléotides comprenant des éléments régulateurs d'ADN de la séquence générale TTN¿X?AA qui lient des protéines régulatrices transcriptionnelles activées en réponse à des molécules de signalisation telles que des cytokines. Cette invention concerne également des structures d'ADN comprenant les séquences d'oligonucléotides, des cellules transfectées avec les structures d'ADN, ainsi que des procédés d'utilisation desdites structures d'ADN et des cellules transfectées pour assurer l'expression régulée de gènes de structure, pour détecter et récupérer des protéines régulatrices de transcription et pour mesurer l'aptitude de composés à agir comme agonistes ou antagonistes de la transcription génique.
Lamb Ian Peter
Seidel H. Martin
Ligand Pharmaceuticals Incorporated
Sim & Mcburney
LandOfFree
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