C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/395 (2006.01) C07K 14/435 (2006.01) C07K 16/14 (2006.01) C07K 16/18 (2006.01) C12N 15/31 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2125673
DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognize and binds DNA damaged or modified by a drug (the anticancer drug, cis-diaminedichloroplatinum (II) or cisplatin) has been identified.
Protéine de reconnaissance spécifique à la structure de l'ADN d'origine eukaryotique et ADN codant ce facteur, ainsi que des sondes spécifiques à la protéine de reconnaissance spécifique à la structure de l'ADN ou à l'ADN la codant, et méthodes de détection de la protéine de reconnaissance spécifique à la structure de l'ADN dans les cellules eukaryotiques. On a notamment identifié un facteur cellulaire de mammifère qui reconnaît sélectivement l'ADN endommagé ou modifié par un médicament (le médicament anticancéreux cis-diaminedichloroplatinum (II) ou cisplatine).
Brown Steven J.
Bruhn Suzanne L.
Donahue Brian A.
Essigmann John M.
Kellett Patti J.
Massachusetts Institute Of Technology
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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